The global health investment landscape is undergoing remarkable changes. Traditional government funders, critical to taking interventions to scale, are making cross-sectoral partnerships to solve global health challenges. Corporations, foundations, and impact investors invest in innovative, sustainable, and replicable solutions that ? when proven effective ? attract government funding, which can then provide continuity and take solutions to scale. Panelists will discuss their roles in this new era of investment and opportunities for pioneering and leveraging these investments.